12
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13
Nov
2024
类器官与器官芯片技术网络研讨会-仪器信息网
China
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Webinar
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![[Translate to chinese:] Brain organoid section (DAPI) acquired using THUNDER Imager Live Cell. Image courtesy of Janina Kaspar and Irene Santisteban, Schäfer Lab, TUM. [Translate to chinese:] Brain organoid section (DAPI) acquired using THUNDER Imager Live Cell. Image courtesy of Janina Kaspar and Irene Santisteban, Schäfer Lab, TUM.](/fileadmin/_processed_/2/7/csm_Tilescan_of_brain_organoid_section_46d510ba4e.jpg)
研究大脑健康的成像类器官模型
小胶质细胞是特化的脑驻留免疫细胞,在大脑发育、平衡和疾病中发挥着至关重要的作用。然而,到目前为止,模拟人脑环境与小胶质细胞之间相互作用的能力还非常有限。
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![Fluorescently stained mouse tibia, imaged with a THUNDER Imager 3D Tissue. Courtesy of Dr. Anjali Kusumbe, University of Oxford, UK.](/fileadmin/academy/2021/Abstracts_Interviews_Webinars/High-resolution_3D_imaging_to_investigate_tissue_ageing_teaser.jpg)
High-resolution 3D Imaging to Investigate Tissue Ageing
Award-winning researcher Dr. Anjali Kusumbe demonstrates age-related changes in vascular microenvironments through single-cell resolution 3D imaging of young and aged organs.
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![](/fileadmin/academy/2021/Abstracts_Interviews_Webinars/Optimizing_THUNDER_platform_for_high-content_slide_scanning_teaser.jpg)
优化 THUNDER 平台以实现高内涵玻片扫描
随着对全组织成像需求的不断增长以及对不同生物标本中 FL 信号定量的需要,HC 成像技术的极限受到了考验,而核心设备的用户可培训性和易用性则成为了成本和效率的问题。在这里,我们展示了在我们的设施中为THUNDER平台开发的可行工作流程,以支持从 KO-小鼠组织分析到人类癌症的各种研究环境需求。
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![](/fileadmin/_processed_/d/b/csm_Criscuolo_cells_teaser_a9341b9f3e.jpg)
改进成像技术以了解细胞器膜细胞动态
了解正常组织和肿瘤组织中的细胞功能,是推动潜在治疗策略研究和了解某些治疗失败原因的关键因素。单细胞分析在生物医学研究中至关重要,它能揭示在癌症等复杂疾病中哪些细胞和分子通路发生了改变。
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![](/fileadmin/_processed_/9/7/csm_Advancing_Cell_Biology_with_Cryo-Correlative_Microscopy_teaser_ce97c3494b.jpg)
Advancing Cell Biology with Cryo-Correlative Microscopy
Correlative light and electron microscopy (CLEM) advances biological discoveries by merging different microscopes and imaging modalities to study systems in 4D. Combining fluorescence microscopy with…