12
–
13
Nov
2024
类器官与器官芯片技术网络研讨会-仪器信息网
China
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Webinar
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![[Translate to chinese:] The role of extracellular signalling mechanisms in the correct development of the human brain [Translate to chinese:] The role of extracellular signalling mechanisms in the correct development of the human brain](/fileadmin/_processed_/a/e/csm_The_role_of_extracellular_signalling_mechanisms_in_the_correct_development_of_the_human_brain_24ae92408c.jpg)
在神经发育过程中,细胞是如何相互交流的?
细胞间通信是大脑发育过程中一个必不可少的过程,它受到多种因素的影响,包括细胞的形态、粘附分子、局部细胞外基质和分泌囊泡。在本次网络研讨会上,您将了解到对这些机制更深入的理解是如何推动对神经发育障碍的理解的。
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![[Translate to chinese:] Brain organoid section (DAPI) acquired using THUNDER Imager Live Cell. Image courtesy of Janina Kaspar and Irene Santisteban, Schäfer Lab, TUM. [Translate to chinese:] Brain organoid section (DAPI) acquired using THUNDER Imager Live Cell. Image courtesy of Janina Kaspar and Irene Santisteban, Schäfer Lab, TUM.](/fileadmin/_processed_/2/7/csm_Tilescan_of_brain_organoid_section_46d510ba4e.jpg)
研究大脑健康的成像类器官模型
小胶质细胞是特化的脑驻留免疫细胞,在大脑发育、平衡和疾病中发挥着至关重要的作用。然而,到目前为止,模拟人脑环境与小胶质细胞之间相互作用的能力还非常有限。
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![[Translate to chinese:] THY1-EGFP labeled neurons in mouse brain processed using the PEGASOS 2 tissue clearing method. Neurons were traced using Aivia’s 3D Neuron Analysis – FL recipe. Image credit: Hu Zhao, Chinese Institute for Brain Research. [Translate to chinese:] THY1-EGFP labeled neurons in mouse brain processed using the PEGASOS 2 tissue clearing method, imaged on a Leica confocal microscope. Neurons were traced using Aivia’s 3D Neuron Analysis – FL recipe. Image credit: Hu Zhao, Chinese Institute for Brain Research.](/fileadmin/_processed_/f/1/csm_Neurons_in_mouse_brain_with_Aivia_3D_Neuron_Analysis_9aa755e1c5.jpg)
借助人工智能,揭示复杂而密集的神经元图像中的洞察
神经元的3D形态学分析通常需要使用不同的成像模式,捕捉多种类型的神经元,并在各种密度下相连的传统Leica SP8显微镜采集多达解神经元的形态,这对许多研究人员来说仍然是一个耗时的挑战。
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![](/fileadmin/_processed_/7/4/csm_Designing_your_Research_Study_with_Multiplexed_IF_Imaging_teaser_8149cd5698.jpg)
利用多重中频成像设计您的研究课题
多重组织分析是一种功能强大的技术,可对单个固定组织样本中的细胞类型位置和细胞类型相互作用进行比较。在多重分析研究开始之前,研究人员通常会提出以下问题: "我如何知道组织中哪些生物标记物是相关的?另外,随着研究问题的发展,我如何转向其他生物标记物?巧妙的研究设计有助于回答现有的问题,并能继续探索研究开始时并不明显的新联系。
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![](/fileadmin/_processed_/1/7/csm_Understanding_motor_sequence_generation_teaser_d9f1d4d6e0.jpg)
Understanding Motor Sequence Generation Across Spatiotemporal Scales
We have developed a microscopy-based pipeline to characterize a developmentally critical behavior at the pupal stage of development, called the ecdysis sequence. We study brain-wide neuronal activity…