![[Translate to chinese:] The role of extracellular signalling mechanisms in the correct development of the human brain The_role_of_extracellular_signalling_mechanisms_in_the_correct_development_of_the_human_brain.jpg](/fileadmin/_processed_/a/e/csm_The_role_of_extracellular_signalling_mechanisms_in_the_correct_development_of_the_human_brain_7969ced402.jpg "[Translate to chinese:] The role of extracellular signalling mechanisms in the correct development of the human brain")
神经发育障碍中的细胞外信号
受到与神经发育障碍相关的突变的启发，慕尼黑路德维希-马克西米利安大学（LMU）的Silvia Cappello教授团队专注于研究调控人类大脑发育的基本分子和细胞机制，特别是细胞外机制。
该团队结合体内小鼠模型和体外人类来源的神经元、脑类器官以及背腹侧组装体，以更好地了解腹侧祖细胞增殖和命运以及人类大脑发育过程中抑制性神经元的迁移和成熟的机制，并应对神经发育障碍的原因。他们特别关注影响细胞间接触、细胞外基质和囊泡分泌的基因突变，因此研究形成大脑的内在和外在机制。这些数据揭示了细胞非自主性机制在神经发育障碍发展中的重要作用。
在整场网络研讨会上，Silvia还将展示如何使用Mica Imaging Microhub成像工作站，结合共聚焦和超高分辨率系统，来支持该团队的研究工作。
![[Translate to chinese:] Multiplexed Cell DIVE imaging of Adult Human Alzheimer’s brain tissue section demonstrating expression of markers specific to astrocytes (GFAP, S100B), microglia (TMEM119, IBA1), AD-associated markers (p-Tau217, β-amyloid) and immune cells such as CD11b+, CD163+, CD4+, and HLA-DRA+, clustered around the β-amyloid plaques.](/fileadmin/_processed_/b/b/csm_Alzheimers_brain_tissue_section_showing_astrocytes_microglia_immune_cells_26ab13cde2.jpg "[Translate to chinese:] Multiplexed Cell DIVE imaging of Adult Human Alzheimer’s brain tissue section demonstrating expression of markers specific to astrocytes , microglia , AD-associated markers and immune cells clustered around the β-amyloid plaques")
![[Translate to chinese:] Multiplexed Cell DIVE imaging to characterize the spatial landscape in Human Alzheimer’s Cortical Tissue](/fileadmin/_processed_/7/2/csm_Human_Alzheimers_Cortical_Tissue_Multiplexed_Cell_DIVE_imaging_b053b78344.jpg "[Translate to chinese:] Multiplexed Cell DIVE imaging to characterize the spatial landscape in Human Alzheimer’s Cortical Tissue")
