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Dive into Pancreatic Cancer Research with the Big Data Viewer
Pancreatic cancer, with a mortality rate near 40%, is challenging to treat due to its proximity to major organs. This story explores the complex biology of pancreatic ductal adenocarcinoma (PDAC),…
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Uncover the Hidden Complexity of Colon Cancer with the Big Data Viewer
Colorectal cancer poses a significant health burden. While surgery is effective initially, some patients develop recurrent secondary disease with poor prognosis, necessitating advanced therapies like…
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Mapping Tumor Immune Landscape with AI-Powered Spatial Proteomics
Spatial mapping of untreated tumors provides an overview of the tumor immune architecture, useful for understanding therapeutic responses. Immunocompetent murine models are essential for identifying…
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![[Translate to chinese:] Multiplexed Cell DIVE imaging of Adult Human Alzheimer’s brain tissue section demonstrating expression of markers specific to astrocytes (GFAP, S100B), microglia (TMEM119, IBA1), AD-associated markers (p-Tau217, β-amyloid) and immune cells such as CD11b+, CD163+, CD4+, and HLA-DRA+, clustered around the β-amyloid plaques.](/fileadmin/_processed_/b/b/csm_Alzheimers_brain_tissue_section_showing_astrocytes_microglia_immune_cells_6f24036a9f.jpg "[Translate to chinese:] Multiplexed Cell DIVE imaging of Adult Human Alzheimer’s brain tissue section demonstrating expression of markers specific to astrocytes , microglia , AD-associated markers and immune cells clustered around the β-amyloid plaques")
Spatial Analysis of Neuroimmune Interactions in Alzheimer’s Disease
Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by neurofibrillary tangles, β-amyloid plaques, and neuroinflammation. These dysfunctions trigger or are exacerbated by…
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A Guide to Spatial Biology
What is spatial biology, and how can researchers leverage its tools to meet the growing demands of biological questions in the post-omics era? This article provides a brief overview of spatial biology…
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![[Translate to chinese:] Salmonella biofilms 3D render](/fileadmin/_processed_/9/6/csm_Salmonella_biofilms_3D_render_b444a820a0.jpg "[Translate to chinese:] Salmonella biofilms 3D render")
探索微生物世界：三维食品基质中的空间相互作用
Micalis 研究所是与 INRAE、AgroParisTech 和巴黎萨克雷大学合作的联合研究单位。其使命是开发食品微生物学领域的创新研究，以促进健康。在这一系列视频中，Micalis…
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![[Translate to chinese:] Multiplexed Cell DIVE imaging to characterize the spatial landscape in Human Alzheimer’s Cortical Tissue](/fileadmin/_processed_/7/2/csm_Human_Alzheimers_Cortical_Tissue_Multiplexed_Cell_DIVE_imaging_e4cf382069.jpg "[Translate to chinese:] Multiplexed Cell DIVE imaging to characterize the spatial landscape in Human Alzheimer’s Cortical Tissue")
使用空间多重化探测人类阿尔茨海默病皮层切片
阿尔茨海默病（AD）是最常见的神经退行性疾病，其特征是认知功能的逐渐下降。对 AD 大脑的空间分析可能揭示细胞关系，从而促进对疾病病因的更好理解。本研究捕捉了 AD 皮层组织成分的全球概述，并强调了 Cell DIVE 成像的简化工作流程，从数据采集到使用 Aivia 软件的基于人工智能的分析，最终实现更快的洞察。
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![[Translate to chinese:] Brightfield image of a pig liver stained with hematoxylin-eosin (HE).](/fileadmin/_processed_/1/3/csm_Pig_Liver_BF_stained_with_hematoxylin-eosin_b2c110c09d.jpg "[Translate to chinese:] Brightfield image of a pig liver stained with hematoxylin-eosin (HE).")
空间代谢组学：探索肿瘤复杂性和治疗见解
在癌症研究中，理解肿瘤细胞与其微环境之间的相互作用至关重要，因为肿瘤微环境显著影响肿瘤进展。空间代谢组学是一种由研究人员开发的新方法，用于研究这一复杂性。通过揭示肿瘤微环境中的空间变化，该方法提供了对其多样化成分及其组织的宝贵见解。这些见解不仅影响临床结果，还为治疗反应提供信息，为个性化治疗策略铺平道路。
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![[Translate to chinese:] Mosaic scan of a Masson-Goldner stained cat brain. Magnification: 20x.](/fileadmin/_processed_/4/d/csm_Cat_Brain_Masson-Goldner_20x_Mosaic_066f4f5801.jpg "[Translate to chinese:] Mosaic scan of a Masson-Goldner stained cat brain. Magnification: 20x.")
基于激光显微切割的稀疏细胞脂质组学分析
通过高覆盖率靶向脂质组学分析稀疏细胞，深入探讨细胞复杂性。这种先进的方法结合了激光显微切割（LMD）和液相色谱-质谱/质谱（LC-MS/MS），揭示了单细胞水平的代谢变化，阐明了糖尿病和肥胖等疾病。通过采用激光显微切割（LMD）获得无污染样本，并使用 SCIEX 7500 系统提高灵敏度，该方法成功检测到 285…
