THUNDER成像系统 Live Cell 和 3D Assay 活细胞培养显微成像系统

Cancer Research

Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer
Hinterleitner, C., Strähle, J., Malenke, E. et al. Nat Commun 12, 7005 (2021). doi.org/10.1038/s41467-021-27303-7

Exosomes produced by melanoma cells significantly influence the biological properties of normal and cancer-associated fibroblasts
Strnadová, K., Pfeiferová, L., Přikryl, P. et al. Histochem Cell Biol 157, 153–172 (2022). doi.org/10.1007/s00418-021-02052-2

Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics
Olmeda D, Cerezo-Wallis D, Mucientes C, Calvo TG, Cañón E, Alonso-Curbelo D, Ibarz N, Muñoz J, Rodriguez-Peralto JL, Ortiz-Romero P, Ortega S, Soengas MS. EMBO Mol Med. 2021 Dec 7;13(12):e12924. doi: 10.15252/emmm.202012924. Epub 2021 Nov 11. PMID: 34762341; PMCID: PMC8649872.

MicroRNA-196a promotes renal cancer cell migration and invasion by targeting BRAM1 to regulate SMAD and MAPK signaling pathways
Cui J, Yuan Y, Shanmugam MK, et al. Int J Biol Sci. 2021;17(15):4254-4270. Published 2021 Oct 17. doi:10.7150/ijbs.60805

Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment
Hong S, You JY, Paek K, et al. Theranostics. 2021;11(19):9687-9704. Published 2021 Sep 27. doi:10.7150/thno.60851

Proteomics analysis identifies PEA-15 as an endosomal phosphoprotein that regulates α5β1 integrin endocytosis
Caliva MJ, Yang WS, Young-Robbins S, et al. Sci Rep. 2021;11(1):19830. Published 2021 Oct 6. doi:10.1038/s41598-021-99348-z

Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity
Langdon CG, Gadek KE, Garcia MR, et al. Nat Commun. 2021;12(1):5520. Published 2021 Sep 17. doi:10.1038/s41467-021-25829-4

Upregulation of ECT2 Predicts Adverse Clinical Outcomes and Increases 5-Fluorouracil Resistance in Gastric Cancer Patients
Zhang H, Geng Y, Sun C, Yu J. J Oncol. 2021;2021:2102890. Published 2021 Jul 28. doi:10.1155/2021/2102890

miR-542-3p Contributes to the HK2-Mediated High Glycolytic Phenotype in Human Glioma Cells
Kim J, Park MW, Park YJ, Ahn JW, Sim JM, Kim S, Heo J, Jeong JH, Lee M, Lim J, Moon J-S.; Genes. 2021; 12(5):633. doi.org/10.3390/genes12050633

Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
Della Chiara G, Gervasoni F, Fakiola M, et al.; Nat Commun. 2021;12(1):2340. Published 2021 Apr 20. doi:10.1038/s41467-021-22544-y

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis
Kantar D, Mur EB, Mancini M, Slaninova V, Salah YB, Costa L, Forest E, Lassus P, Géminard C, Boissière-Michot F, Orsetti B, Theillet C, Colinge J, Benistant C, Maraver A, Heron-Milhavet L, Djiane A. Sci Rep. 2021 Mar 11;11(1):5752. doi: 10.1038/s41598-021-85056-1. PMID: 33707576; PMCID: PMC7952706.

ZNF224 is a Mediator of TGF-β Pro-oncogenic Function in Melanoma
Cesaro E, Pastore A, Polverino A, et al. Research Square; 2021. DOI: 10.21203/rs.3.rs-278700/v1. 

The Expression of the Cancer-Associated lncRNA Snhg15 Is Modulated by EphrinA5-Induced Signaling
Pensold D, Gehrmann J, Pitschelatow G, Walberg A, Braunsteffer K, Reichard J, Ravaei A, Linde J, Lampert A, Costa IG, Zimmer-Bensch G. Int J Mol Sci. 2021 Jan 29;22(3):1332. doi: 10.3390/ijms22031332. PMID: 33572758; PMCID: PMC7866228.

Cancer cells adapt FAM134B-BiP complex mediated ER-phagy to survive hypoxic stress
Sandhya Chipurupalli, Raja Ganesan, Giulia Martini, Luigi Mele, Elango Kannan, Vigneshwaran Namasivayam, Vincenzo Desiderio, Nirmal Robinson
bioRxiv 2021.02.05.429931; doi: doi.org/10.1101/2021.02.05.429931

Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia
Xiong, H., Mancini, M., Gobert, M., Shen, S., Furtado, G. C., Lira, S. A., Parkhurst, C. N., Garambois, V., Brengues, M., Tadokoro, C. E., Trimarchi, T., Gómez-López, G., Singh, A., Khiabanian, H., Minuzzo, S., Indraccolo, S., Lobry, C., Aifantis, I., Herranz, D., Lafaille, J. J., Maraver, A. (2021). Theranostics, 11(4), 1594–1608. doi.org/10.7150/thno.48067

Multiparametric Analysis of Focal Adhesions in Bidimensional Substrates
Talayero, Vanessa & vicente-manzanares, Miguel. (2020). 10.1007/978-1-0716-0962-0_3

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis
Ilaria Guccini, Ajinkya Revandkar, Mariantonietta D'Ambrosio, Manuel Colucci, Emiliano Pasquini, Simone Mosole, Martina Troiani, Daniela Brina, Raheleh Sheibani-Tezerji, Angela Rita Elia, Andrea Rinaldi, Nicolò Pernigoni, Jan Hendrik Rüschoff, Susanne Dettwiler, Angelo M. De Marzo, Emmanuel S. Antonarakis, Costanza Borrelli, Andreas E. Moor, Ramon Garcia-Escudero, Abdullah Alajati, Giuseppe Attanasio, Marco Losa, Holger Moch, Peter Wild, Gerda Egger, Andrea Alimonti,
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis, Cancer Cell, 2020, ISSN 1535-6108

MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells
Noriyuki Sumida, Emmanouil G Sifakis, Narsis A Kiani, Anna Lewandowska Ronnegren, Barbara A Scholz, Johanna Vestlund, David Gomez-Cabrero, Jesper Tegner, Anita Göndör, Rolf Ohlsson
Nucleic Acids Research, Volume 48, Issue 19, 4 November 2020, Pages 10867–10876, doi.org/10.1093/nar/gkaa817
Published: 13 October 2020

BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF
Pulkkinen, H.H., Kiema, M., Lappalainen, J.P. et al. BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF. Angiogenesis (2020). Published: October 2020

Pharmacological STING activation is a potential alternative to overcome drug-resistance in melanoma
Chipurupalli S, Ganesan R, Dhanabal SP, Kumar MS and Robinson N (2020) Pharmacological STING Activation Is a Potential Alternative to Overcome Drug-Resistance in Melanoma. Front. Oncol. 10:758. doi: 10.3389/fonc.2020.00758, May 2020

Cholesterol Homeostasis Modulates Platinum Sensitivity in Human Ovarian Cancer
Daniela Criscuolo, Rosario Avolio, Giovanni Calice, Chiara Laezza, Simona Paladino, Giovanna Navarra, Francesca Maddalena, Fabiana Crispo, Cristina Pagano, Maurizio Bifulco, Matteo Landriscina, Danilo Swann Matassa, and Franca Esposito
Cells 2020, 9(4), 828; March 2020

Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments
Wei D, Yang Y, Ricketts CJ, et al. Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments. Genes Chromosomes Cancer. 2020;59(8):472-483. doi:10.1002/gcc.22847

Immunology

XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells
Adam Wahida, Madeleine Müller, Andreas Hiergeist, Bastian Popper, Katja Steiger, Caterina Branca, Markus Tschurtschenthaler, Thomas Engleitner, Sainitin Donakonda, Jordy De Coninck, Rupert Öllinger, Marie K. Pfautsch, Nicole Müller, Miguel Silva, Sinem Usluer, Erik Thiele Orberg, Jan P. Böttcher, Nicole Pfarr, Martina Anton, Julia B. Slotta-Huspenina, Andreas G. Nerlich, Tobias Madl, Marijana Basic, André Bleich, Geert Berx, Jürgen Ruland, Percy A. Knolle, Roland Rad, Timon E. Adolph, Peter Vandenabeele, Hirokazu Kanegane, André Gessner, Philipp J. Jost, Monica Yabal; Science Immunology, 2021, eabf7235; 10.1126/sciimmunol.abf7235 [doi]

Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice
Dong, R., Han, Y., Jiang, L. et al.; J Neuroinflammation 19, 64 (2022). doi.org/10.1186/s12974-022-02424-y

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting
Zimmer, M.M., Kibe, A., Rand, U. et al.; Nat Commun 12, 7193 (2021). doi.org/10.1038/s41467-021-27431-0

Involvement of Ischemia-driven 5LPOX-RvE1-ChemR23 axis in the resolution of post-CABG inflammation in Coronary Arteries
Finosh Thankam, Victoria E. D. Wilson, Mohamed M Radwan et al. 17 November 2021, PREPRINT (Version 1) available at Research Square; doi.org/10.21203/rs.3.rs-1064912/v1

A fluorescence-based, gain-of-signal, live cell system to evaluate SARS-CoV-2 main protease inhibition
Dey-Rao R, Smith GR, Timilsina U, et al. Antiviral Res. 2021;195:105183. doi:10.1016/j.antiviral.2021.105183

Asthmatic allergen inhalation sensitises carotid bodies to lysophosphatidic acid
Jendzjowsky NG, Roy A, Wilson RJA. J Neuroinflammation. 2021;18(1):191. Published 2021 Aug 31. doi:10.1186/s12974-021-02241-9

Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways
Oh, S., Bournique, E., Bowen, D. et al. Nat Commun 12, 4917 (2021), Published 13 August 2021. doi.org/10.1038/s41467-021-25203-4

Tissue clearing and 3D imaging - putting immune cells into context
Hofmann J, Keppler SJ. J Cell Sci. 2021;134(15):jcs258494. doi:10.1242/jcs.258494 

Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
Lentini G, Ben Chaabene R, Vadas O, et al.; Nat Commun. 2021;12(1):3788. Published 2021 Jun 18. doi:10.1038/s41467-021-24083-y

Phosphatidic acid-mediated binding and mammalian cell internalization of the Vibrio cholerae cytotoxin MakA
Nadeem A, Alam A, Toh E, Myint SL, Ur Rehman Z, Liu T, Bally M, Arnqvist A, Wang H, Zhu J, Persson K, Uhlin BE, Wai SN. PLoS Pathog. 2021 Mar 18;17(3):e1009414. doi: 10.1371/journal.ppat.1009414. PMID: 33735319; PMCID: PMC8009392.

Human endogenous retrovirus-enveloped baculoviral DNA vaccines against MERS-CoV and SARS-CoV2
Cho, H., Jang, Y., Park, KH. et al. npj Vaccines 6, 37 (2021). doi.org/10.1038/s41541-021-00303-w

MFG-E8 Plays an Important Role in Attenuating Cerulein-Induced Acute Pancreatitis in Mice
Bu HF, Subramanian S, Geng H, Wang X, Liu F, Chou PM, Du C, De Plaen IG, Tan XD. Cells. 2021 Mar 25;10(4):728. doi: 10.3390/cells10040728. PMID: 33806041.

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection
Mills, Richard J et al.; Cell vol. 184,8 (2021): 2167-2182.e22. doi:10.1016/j.cell.2021.03.026

Electrogenic and hydrocarbonoclastic biofilm at the oil-water interface as microbial responses to oil spill
Emilio D'Ugo, Lucia Bertuccini, Francesca Spadaro, Roberto Giuseppetti, Francesca Iosi, Fabio Santavenere, Fausto Giuliani, Massimo Gricia, Andrea Rodomonte, Nicola Lovecchio, Arghya Mukherjee, Paola Bucci, Milena Bruno, Emilia Stellacci, Antonietta Bernardo, Fabio Magurano, Water Research X, 2021, 100096, ISSN 2589-9147, doi.org/10.1016/j.wroa.2021.100096.

COVID-19-associated nephropathy includes tubular necrosis and capillary congestion, with evidence of SARS-CoV-2 in the nephron
Antoine Bouquegneau, Pauline Erpicum, Stéphanie Grosch, Lionel Habran, Olivier Hougrand, Justine Huart, Jean-Marie Krzesinski, Benoît Misset, Marie-Pierre Hayette, Philippe Delvenne, Christophe Bovy, Dominik Kylies, Tobias B. Huber, Victor G. Puelles, Pierre Delanaye, Francois Jouret; Kidney360 Feb 2021, 10.34067/KID.0006992020; DOI: 10.34067/KID.0006992020

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients
Yu Zhao, Christoph Kilian, Jan-Eric Turner, Lidia Bosurgi, Kevin Roedl, Patricia Bartsch, Ann-Christin Gnirck, Filippo Cortesi, Christoph Schultheiß, Malte Hellmig, Leon U.B. Enk, Fabian Hausmann, Alina Borchers, Milagros N. Wong, Hans-Joachim Paust, Francesco Siracusa, Nicola Scheibel, Marissa Herrmann, Elisa Rosati, Petra Bacher, Dominik Kylies, Dominik Jarczak, Marc Lütgehetmann, Susanne Pfefferle, Stefan Steurer, Julian Schulze zur-Wiesch, Victor G. Puelles, Jan-Peter Sperhake, Marylyn M. Addo, Ansgar W. Lohse, Mascha Binder, Samuel Huber, Tobias B. Huber, Stefan Kluge, Stefan Bonn, Ulf Panzer, Nicola Gagliani, Christian F. Krebs; Science Immunology 23 Feb 2021: Vol. 6, Issue 56, eabf6692 DOI: 10.1126/sciimmunol.abf6692

Universally available herbal teas based on sage and perilla elicit potent antiviral activity against SARS-CoV-2 in vitro
Vu Thuy Khanh Le-Trilling, Denise Mennerich, Corinna Schuler, Yulia Flores-Martinez, Benjamin Katschinski, Ulf Dittmer, Mirko Trilling; bioRxiv 2020.11.18.388710; doi: doi.org/10.1101/2020.11.18.388710

DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
Jianlu Lv, Wei Wang, Xialin Zhu, Xiaoju Xu, Qiuying Yan, Jian Lu, Xiaofan Shi, Zhengyu Wang, Jinpei Zhou, Xi Huang, Jiaying Wang, Wenhu Duan, Xu Shen
Science Direct, Published: 30 July 2020

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity
Abigail Jarret, Ruaidhrí Jackson, Coco Duizer, Yuval Kluger, Roni Novarski, et. al.
Research Journal: Cell; Volume 180, ISSUE 1, P50-63.e12, January 09, 2020

Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii
Nicolò Tosetti, Nicolas Dos Santos Pacheco, Eloïse Bertiaux, Bohumil Maco, Lorène Bournonville, Virginie Hamel, Paul Guichard, Dominique Soldati-Favre; eLife 2020;9:e56635 doi: 10.7554/eLife.56635
https://elifesciences.org/articles/56635

Neurobiology

Mutant Cu/Zn Superoxide Dismutase (A4V) Turnover Is Altered in Cells Containing Inclusions  
Farrawell Natalie E., Yerbury Justin J.; Frontiers in Molecular Neuroscience, Vol. 14, 2021; DOI:10.3389/fnmol.2021.771911

Potentiation of amyloid beta phagocytosis and amelioration of synaptic dysfunction upon FAAH deletion in a mouse model of Alzheimer's disease
Ruiz-Pérez, G., Ruiz de Martín Esteban, S., Marqués, S. et al. J Neuroinflammation 18, 223 (2021). doi.org/10.1186/s12974-021-02276-y

Human Trisomic iPSCs from Down Syndrome Fibroblasts Manifest Mitochondrial Alterations Early during Neuronal Differentiation
Mollo N, Esposito M, Aurilia M, et al. Biology (Basel). 2021;10(7):609. Published 2021 Jun 30. doi:10.3390/biology10070609

Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats
Oliveira VEM, Lukas M, Wolf HN, et al. Nat Commun. 2021;12(1):2900. Published 2021 May 18. doi:10.1038/s41467-021-23064-5

Neuron Replating, a Powerful and Versatile Approach to Study Early Aspects of Neuron Differentiation
Schneider F, Duong TA, Rust MB.; eNeuro. 2021;8(3):ENEURO.0536-20.2021. Published 2021 May 20. doi:10.1523/ENEURO.0536-20.2021

Synaptic disruption and CREB-regulated transcription are restored by K+ channel blockers in ALS
Catanese A, Rajkumar S, Sommer D, et al.; EMBO Mol Med. 2021;13(7):e13131. doi:10.15252/emmm.202013131

Top-down acetylcholine signaling via olfactory bulb vasopressin cells contributes to social discrimination in rats
Suyama H, Egger V, Lukas M.; Commun Biol. 2021;4(1):603. Published 2021 May 21. doi:10.1038/s42003-021-02129-7

Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats
Oliveira VEM, Lukas M, Wolf HN, et al.; Nat Commun. 2021;12(1):2900. Published 2021 May 18. doi:10.1038/s41467-021-23064-5

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases
Min Woo Park, Hyeon Woo Cha, Junhyung Kim, Jung Han Kim, Haesung Yang, Sunmi Yoon, Napissara Boonpraman, Sun Shin Yi, Ik Dong Yoo, Jong-Seok Moon; Redox Biology, Volume 41, 2021, 101947, ISSN 2213-2317, doi.org/10.1016/j.redox.2021.101947.

Perineuronal nets are under the control of type-5 metabotropic glutamate receptors in the developing somatosensory cortex
Mascio, G., Bucci, D., Notartomaso, S. et al. Transl Psychiatry 11, 109 (2021). doi.org/10.1038/s41398-021-01210-3

Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer's Disease
Yoo ID, Park MW, Cha HW, Yoon S, Boonpraman N, Yi SS, Moon JS. Int J Mol Sci. 2020 Oct 23;21(21):7862. doi: 10.3390/ijms21217862. PMID: 33114015; PMCID: PMC7660350.

DNA Methyltransferase 1 (DNMT1) Acts on Neurodegeneration by Modulating Proteostasis-Relevant Intracellular Processes
Bayer C, Pitschelatow G, Hannemann N, Linde J, Reichard J, Pensold D, Zimmer-Bensch G. Int J Mol Sci. 2020 Jul 30;21(15):5420. doi: 10.3390/ijms21155420. PMID: 32751461; PMCID: PMC7432412.

Neural mechanisms of female aggression: Implications on the oxytocin and vasopressin systems
Uni Regensburg, Vinícius Elias de Moura Oliveira, 2020; epub.uni-regensburg.de/43275/1/Thesis_VO_final%20printing%20library.pdf

Microglia orchestrate neuronal activity in brain organoids
Ilkka Fagerlund, Antonios Dougalis, Anastasia Shakirzyanova, Mireia Gómez-Budia, Henna Konttinen, Sohvi Ohtonen, Fazaludeen Feroze, Marja Koskuvi, Johanna Kuusisto, Damián Hernández, Alice Pebay, Jari Koistinaho, Sarka Lehtonen, Paula Korhonen, Tarja Malm
bioRxiv 2020.12.08.416388; doi: doi.org/10.1101/2020.12.08.416388

Unraveling the pathology of different disease severities in human cerebral organoid models of LIS1-lissencephaly
Krefft, Olivia; DOI: doi.org/10.11588/heidok.00029195

Mating-induced central release of oxytocin: Implication for social fear extinction 
urn:nbn:de:bvb:355-epub-440663. DOI: 10.5283/epub.44066

Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices
Imig C, López-Murcia FJ, Maus L, García-Plaza IH, Mortensen LS, Schwark M, Schwarze V, Angibaud J, Nägerl UV, Taschenberger H, Brose N, Cooper BH. Neuron. 2020 Dec 9;108(5):843-860.e8. doi: 10.1016/j.neuron.2020.09.004. Epub 2020 Sep 28. PMID: 32991831; PMCID: PMC7736621.

Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage
Michelle A.Johnson, Qiudong Deng, Georgia Taylor, Zachary T. McEachin, Anthony W.S. Chan, Jessica Root, Gary J.Bassell, Thomas Kukar
Science Direct, Published: 2020 by Elsevier Inc.

Neuronal Lhx1 expression is regulated by DNMT1-dependent modulation of histone marks
Judit Symmank, Cathrin Bayer, Julia Reichard, Daniel Pensold & Geraldine Zimmer-Bensch (2020): Neuronal Lhx1 expression is regulated by DNMT1-dependent modulationof histone marks, Epigenetics, DOI: 10.1080/15592294.2020.1767372, May 2020

Characterization of a cell bridge variant connecting the nodose and superior cervical ganglia in the mouse: Prevalence, anatomical features, and practical implications
Angie L. Bookout, Laurent Gautron; First published: 01 May 2020; doi.org/10.1002/cne.24936
Funding information: National Institute of Diabetes and Digestive and Kidney Diseases, Grant/Award Number: 5 K01 DK116926‐02; NIH, Grant/Award Number: 1S10OD021684‐01; University of Texas Southwestern Medical Center, Grant/Award Number: Irwin & Irma Grossman Research Fund for Type I Dia

Developmental Biology

Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)
Koopmans, T., van Beijnum, H., Roovers, E.F. et al. npj Regen Med 6, 78 (2021). doi.org/10.1038/s41536-021-00188-2

Degradative tubular lysosomes link pexophagy to starvation and early aging in C. elegans
Dolese DA, Junot MP, Ghosh B, Butsch TJ, Johnson AE, Bohnert KA. [published online ahead of print, 2021 Dec 12]. Autophagy. 2021;1-12. doi:10.1080/15548627.2021.1990647

The Arabidopsis mature endosperm promotes seedling cuticle formation via release of sulfated peptides
Julien De Giorgi, Christelle Fuchs, Mayumi Iwasaki, Woohyun Kim, Urszula Piskurewicz, Kay Gully, Anne Utz-Pugin, Laurent Mène-Saffrané, Patrice Waridel, Christiane Nawrath, Fiamma Paolo Longoni, Satoshi Fujita, Sylvain Loubéry, Luis Lopez-Molina; Developmental Cell,
Volume 56, Issue 22, 2021, Pages 3066-3081.e5, ISSN 1534-5807, doi.org/10.1016/j.devcel.2021.10.005

Sperm Cyst “Looping”: A Developmental Novelty Enabling Extreme Male Ornament Evolution
Syed ZA, Dallai R, Nasirzadeh N, Brill JA, O’Grady PM, Cong S, Leef EM, Rice S, Asif A, Nguyen S, Hansen MM, Dorus S, Pitnick S. Cells. 2021; 10(10):2762. doi.org/10.3390/cells10102762

The Spin1 interactor, Spindoc, is dispensable for meiotic division, but essential for haploid spermatid development in mice
Jiang X, Zhu X, Cheng Y, et al. Reprod Biol Endocrinol. 2021;19(1):144. Published 2021 Sep 15. doi:10.1186/s12958-021-00828-8

GRDN-1/Girdin regulates dendrite morphogenesis and cilium position in two specialized sensory neuron types in C. elegans
Nechipurenko I, Lavrentyeva S, Sengupta P. Dev Biol. 2021 Apr;472:38-51. doi: 10.1016/j.ydbio.2020.12.022. Epub 2021 Jan 16. PMID: 33460640; PMCID: PMC7956162.

Scanning Various Nanomaterials and Variable Camouflages to Evaluate the Biocompatibility in Multi-organs of Embryos
Bin Zheng, Mingming Guo, Meijun Pang, Dong Ming; DOI: 10.21203/rs.3.rs-99384/v1

Ischemic tolerance and cardiac repair in the African spiny mouse
Tim Koopmans, Henriette van Beijnum, Elke F. Roovers, Divyanshu Malhotra, Antonio Tomasso, Jochem Boeter, Danielle Versteeg, Eva van Rooij, Kerstin Bartscherer
bioRxiv 2021.01.07.425783; doi: doi.org/10.1101/2021.01.07.425783

FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age
García-Prat, L., Perdiguero, E., Alonso-Martín, S. et al. Nat Cell Biol 22, 1307–1318 (2020). doi.org/10.1038/s41556-020-00593-7

Transgenesis and web resources in quail
Olivier Serralbo, David Salgado, Nadège Véron, Caitlin Cooper, Marie-Julie Dejardin, Timothy Doran, Jérome Gros, Christophe Marcelle; Copyright: 2020, Serralbo et al.
eLife 2020;9:e56312 doi: 10.7554/eLife.56312

Left-right asymmetric heart jogging increases the robustness of dextral heart looping in zebrafish
Grimes D, Patterson V, Luna-Arvizu G, Schottenfeld-Roames J, Irons Z, et. al. 
Developmental Biology, 2019

Two-step mechanism for selective incorporation of lncRNA into a chromatin modifier
Marisa Müller, Tamas Schauer, Silke Krause, Raffaella Villa, Andreas W Thomae, Peter B Becker, Two-step mechanism for selective incorporation of lncRNA into a chromatin modifier, Nucleic Acids Research, gkaa492

Discrete regulation of β-catenin-mediated transcription governs identity of intestinal epithelial stem cells
Costanza Borrelli, Tomas Valenta, Kristina Handler, Karelia Vélez, Giulia Moro, Atefeh Lafzi, Laura de Vargas Roditi, George Hausmann, Andreas E Moor, Konrad Basler; bioRxiv 2020.05.19.103499; doi: doi.org/10.1101/2020.05.19.103499

A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells
Geng, B., Choi, K., Wang, S. et al. A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells. Acta Pharmacol Sin (2020). doi.org/10.1038/s41401-020-0452-0

Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination
Hatice O. Ozguldez, Rui Fan, Ivan Bedzhov
Development 2020 : dev.190371 doi: 10.1242/dev.190371 Published 15 June 2020, by The Company of Biologists Ltd

Physiology

CXCL1-Triggered PAD4 Cytoplasmic Translocation Enhances Neutrophil Adhesion through Citrullination of PDIA1
Jiro Aoyama, Mizuko Osaka, Michiyo Deushi, Shoichi Hosoya, Akihito Ishigami, Taketoshi Maehara, Masayuki Yoshida; Journal of Atherosclerosis and Thrombosis, 2022, Volume 29, Issue 9, Pages 1307-1318, Released on J-STAGE September 01, 2022, Advance online publication December 08, 2021, Online ISSN 1880-3873, Print ISSN 1340-3478, doi.org/10.5551/jat.63237

ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function
Cortés Sanchón, A., Santhosh Kumar, H., Mantovani, M. et al. Commun Biol 4, 1350 (2021). doi.org/10.1038/s42003-021-02873-w

The visual opsin and phototransduction pathway genes associated with eye reduction and loss in bat flies (streblidae, nyceteribiidae)
Atkins, Melissa Leigh; 2021; University of Hawai'i at Manoa; hdl.handle.net/10125/76493

Dehydrated human amniotic membrane modulates canonical Wnt signaling in multiple cell types in vitro
Moreno SE, Massee M, Bara H, Koob TJ. Eur J Cell Biol. 2021;100(5-6):151168. doi:10.1016/j.ejcb.2021.151168

In Vitro Modelling of Barrier Impairment Associated with Gastro-Oesophageal Reflux Disease (GERD)
Meloni M, Buratti P, Carriero F, Ceriotti L. Clin Exp Gastroenterol. 2021;14:361-373. Published 2021 Sep 8. doi:10.2147/CEG.S325346 

CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases
Wall JM, Basu A, Zunica ERM, et al. Dis Model Mech. 2021;14(7):dmm048603. doi:10.1242/dmm.048603

Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells
Borrelli, C., Valenta, T., Handler, K. et al. Nat Commun 12, 1368 (2021). doi.org/10.1038/s41467-021-21591-9

In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease
Bose SK, White BM, Kashyap MV, et al. Nat Commun. 2021;12(1):4291. Published 2021 Jul 13. doi:10.1038/s41467-021-24443-8

Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis
Cheng SY, Luo Y, Malachi A, et al. Hum Gene Ther. 2021;32(13-14):649-666. doi:10.1089/hum.2021.132

HK2 Mediated Glycolytic Metabolism in Mouse Photoreceptors Is Not Required to Cause Late Stage Age-Related Macular Degeneration-Like Pathologies
Cheng SY, Malachi A, Cipi J, et al. Biomolecules. 2021;11(6):871. Published 2021 Jun 11. doi:10.3390/biom11060871

Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus
Madhu LN, Kodali M, Attaluri S, et al.; Redox Biol. 2021;43:101973. doi:10.1016/j.redox.2021.101973

Dehydrated Human Amniotic Membrane Inhibits Myofibroblast Contraction through the Regulation of the TGFβ‒SMAD Pathway In Vitro
Sarah E. Moreno, Michelle Massee, Thomas J. Koob; Open AccessPublished:May 05, 2021DOI:https://doi.org/10.1016/j.xjidi.2021.100020

Novel Dent Disease 1 cellular models reveal biological processes underlying ClC-5 loss-of-function
Durán M, Burballa C, Cantero-Recasens G, et al.; [published online ahead of print, 2021 May 13]. Hum Mol Genet. 2021;ddab131. doi:10.1093/hmg/ddab131

AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction
Hinkel R, Batkai S, Bähr A, et al.; J Am Coll Cardiol. 2021;77(23):2923-2935. doi:10.1016/j.jacc.2021.04.028

Specific Functional Features of the Cell Integrity MAP Kinase Pathway in the Dimorphic Fission Yeast Schizosaccharomyces japonicus
Gómez-Gil E, Franco A, Vázquez-Marín B, Prieto-Ruiz F, Pérez-Díaz A, Vicente-Soler J, Madrid M, Soto T, Cansado J.; Journal of Fungi. 2021; 7(6):482. doi.org/10.3390/jof7060482 

Association of hypoxia and mitochondrial damage associated molecular patterns in the pathogenesis of vein graft failure: a pilot study
Finosh G Thankam, Joseph G Ayoub, Mohamed M Radwan Ahmed, Aleem Siddique, Thomas C Sanchez, Rafael A Peralta, Thomas J Pennington, Devendra K Agrawal, Translational Research, Volume 229, 2021, Pages 38-52, ISSN 1931-5244, 
doi.org/10.1016/j.trsl.2020.08.010.

Molecular imaging of fibroblast activity after myocardial infarction using a ⁶⁸Ga-labelled fibroblast activation protein inhibitor FAPI-04
Varasteh Z, Mohanta S, Robu S, Braeuer M, Li Y, et. al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
2019 pp: jnumed.119.226993

Bmi1 inhibitor PTC-209 promotes Chemically-induced Direct Cardiac Reprogramming of cardiac fibroblasts into cardiomyocytes
Gianluca Testa, Michele Russo, Giorgia Di Benedetto, Matteo Barbato, Silvia Parisi, Flora Pirozzi, Carlo Gabriele Tocchetti, Pasquale Abete, Domenico Bonaduce, Tommaso Russo & Fabiana Passaro
Nature, Scientific Reports 10, Article numer: 7129 (2020)

Affinity Proteomics Identifies Novel Functional Modules Related to Adhesion GPCRs
Barbara Knapp, Jens Roedig, Karsten Boldt, Jacek Krzysko, Nicola Horn, Marius Ueffing, Uwe Wolfrum; First published: 22 August 2019; doi: 10.1111/nyas.14220

Biotechnology/Bioengineering

Three-dimensional dynamics optical coherence tomography for tumor spheroid evaluation
El-Sadek IA, Miyazawa A, Shen LT, et al. Biomed Opt Express. 2021;12(11):6844-6863. Published 2021 Oct 12. doi:10.1364/BOE.440444

3D Confinement Regulates Cell Life and Death
Oksana Y. Dudaryeva, Aurelia Bucciarelli, Giovanni Bovone, Florian Huwyler, Shibashish Jaydev, Nicolas Broguiere, Marwa al-Bayati, Marco Lütolf, Mark W. Tibbitt; First published: 24 September 2021; doi.org/10.1002/adfm.202104098

New application for the identification and differentiation of microplastics based on fluorescence lifetime imaging microscopy (FLIM)
Monteleone, Adrian & Wenzel, Folker & Langhals, Heinz & Dietrich, Daniel. (2020). Journal of Environmental Chemical Engineering. 9. 104769. 10.1016/j.jece.2020.104769. 

3D Airway Organoid Model to Assess Infectivity of Emerging Viruses Using Corning® Matrigel® Matrix-3D Plates (CLS-AN-612)   
Biocompare, April 16, 2021

IBEX: An open and extensible method for high content multiplex imaging of diverse tissues
Andrea J. Radtke, Colin J. Chu, Ziv Yaniv, Li Yao, James Marr, Rebecca T. Beuschel, Hiroshi Ichise, Anita Gola, Juraj Kabat, Bradley Lowekamp, Emily Speranza, Joshua Croteau, Nishant Thakur, Danny Jonigk, Jeremy Davis, Jonathan M. Hernandez, Ronald N. Germain; arxiv.org/abs/2107.11364

Extra Cellular Matrix Deposition and Assembly in Dermis Spheroids
Rescigno F, Ceriotti L, Meloni M. Clin Cosmet Investig Dermatol. 2021;14:935-943. Published 2021 Jul 21. doi:10.2147/CCID.S316707

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
Rothgangl T, Dennis MK, Lin PJC, et al. Nat Biotechnol. 2021;39(8):949-957. doi:10.1038/s41587-021-00933-4

Introducing an Efficient In Vitro Cornea Mimetic Model for Testing Drug Permeability
Žiniauskaitė A, Cėpla V, Jelinskas T, Eimont R, Ulčinas A, Aldonytė R, Valiokas R, Kalesnykas G, Hakkarainen JJ.; Sci. 2021; 3(3):30. doi.org/10.3390/sci3030030

Identification of efficient prokaryotic cell-penetrating peptides with applications in bacterial biotechnology
Lee HM, Ren J, Tran KM, Jeon BM, Park WU, Kim H, Lee KE, Oh Y, Choi M, Kim DS, Na D. Commun Biol. 2021 Feb 15;4(1):205. doi: 10.1038/s42003-021-01726-w. PMID: 33589718; PMCID: PMC7884711.

Cas9-expressing chickens and pigs as resources for genome editing in livestock
Rieblinger B, Sid H, Duda D, Bozoglu T, Klinger R, Schlickenrieder A, Lengyel K, Flisikowski K, Flisikowska T, Simm N, Grodziecki A, Perleberg C, Bähr A, Carrier L, Kurome M, Zakhartchenko V, Kessler B, Wolf E, Kettler L, Luksch H, Hagag IT, Wise D, Kaufman J, Kaufer BB, Kupatt C, Schnieke A, Schusser B. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2022562118. doi: 10.1073/pnas.2022562118. PMID: 33658378.

Moving Towards Standardized Toxicity Testing Procedures with Particulates by Dietary Exposure of Gammarids
Götz, Astrid & Imhof, Hannes & Geist, Juergen & Beggel, Sebastian. (2021). Environmental Toxicology and Chemistry. 10.1002/etc.4990. 

Using autofluorescence for microplastic detection : Heat treatment increases the autofluorescence of microplastics
Monteleone, Adrian; Brandau, Lena; Schary, Weronika; Wenzel, Folker; Year of publication: 2020; Published in: Clinical Hemorheology and Microcirculation ; 76 (2020), 4. - pp. 473-493. - IOS Press. - ISSN 1386-0291. - eISSN 1875-8622; Pubmed ID: 33216019; DOI: dx.doi.org/10.3233/CH-209223

High‐throughput evolutionary optimization of the induction medium towards recombinant protein production in BY‐2 tobacco
Jan Sadoch, Monika Pyc, Anna Urbanowicz, Adam Iglewski, Radosław Pilarski; First published: 10 October 2020; doi.org/10.1002/bit.27594

The Collagen-Based Medical Device MD-Tissue Acts as a Mechanical Scaffold Influencing Morpho-Functional Properties of Cultured Human Tenocytes
Randelli, F.; Sartori, P.; Carlomagno, C.; Bedoni, M.; Menon, A.; Vezzoli, E.; Sommariva, M.; Gagliano, N. Cells 2020, 9, 2641. doi.org/10.3390/cells9122641 

Assisting PNA Transport Through Cystic Fibrosis Human Airway Epithelia With Biodegradable Hybrid Lipid-Polymer Nanoparticles
Marika Comegna, Gemma Conte, Andrea Falanga, Maria Marzano, Gustavo Cernera, Antonella Di Lullo, Felice Amato, Nicola Borbone, Stefano D'Errico, Francesca Ungaro, Ivana d'Angelo, Giorgia Oliviero, Giuseppe Castaldo; DOI 10.21203/rs.3.rs-111943/v1

Optical coherence tomography-based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids
Ibrahim Abd El-Sadek, Arata Miyazawa, Larina Tzu-Wei Shen, Shuichi Makita, Shinichi Fukuda, Toshiharu Yamashita, Yuki Oka, Pradipta Mukherjee, Satoshi Matsusaka, Tetsuro Oshika, Hideaki Kano, and Yoshiaki Yasuno
Biomedical Optics Express Vol. 11, Issue 11, pp. 6231-6248 (2020)

Utility of direct 3D co-culture model for chondrogenic differentiation of mesenchymal stem cells on hyaluronan scaffold (Hyaff-11)
Iwona Deszcz, Anna Lis-Nawara, Piotr Grelewski, Szymon Dragan, Julia Bar
Regenerative Biomaterials, rbaa026, Published: 23 August 2020

Screening method to identify hydrogel formulations that facilitate myotube formation from encapsulated primary myoblasts
Dhananjay V. Deshmukh, Nils Pasquero, Gajraj Rathore, Joel Zvick, Ori Bar‐Nur, Jurg Dual, Mark W. Tibbitt
First published: 20 August 2020; doi.org/10.1002/btm2.10181

In Vivo Bioengineering of Fluorescent Conductive Protein-Dye Microfibers
Maria Moros, Francesca Di Maria, Principia Dardano, Giuseppina Tommasini, Hiram Castillo-Michel, Alessandro Kovtun, Mattia Zangoli, Martina Blasio, Luca De Stefano, Angela Tino, Giovanna Barbarella, Claudia Tortiglione; Published April 24, 2020, by ScienctDirect. doi.org/10.1016/j.isci.2020.101022

Performance of mycelial biomass and exopolysaccharide from Malaysian Ganoderma lucidum for the fungivore red hybrid Tilapia (Oreochromis sp.) in Zebrafish embryo
Norhidayah Mohd Taufek, Hanis H.Harith, Muhamad HafizAbd Rahim, Zul lham, Neil Rowan, Wan Abd Al Qadr Imad Wan-Mohtar, Aquaculture Reports, ISSN: 2352-5134, Vol: 17, Page: 100322, 2020

Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold
Betriu, N.; Jarrosson-Moral, C.; Semino, C.E.
Biomolecules 2020, 10, 684.

Transgenesis and web resources in quail
Olivier Serralbo, David Salgado, Nadège Véron, Caitlin Cooper, Marie-Julie Dejardin, Timothy Doran, Jérome Gros, Christophe Marcelle; eLife 2020;9:e56312 doi: 10.7554/eLife.56312

A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells
Geng, B., Choi, K., Wang, S. et al. A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells. Acta Pharmacol Sin (2020). doi.org/10.1038/s41401-020-0452-0

Biochemistry

Scaffolding protein CcmM directs multiprotein phase separation in β-carboxysome biogenesis
Zang, K., Wang, H., Hartl, F.U. et al. Nat Struct Mol Biol 28, 909–922 (2021). doi.org/10.1038/s41594-021-00676-5

Convergent olfactory trace amine-associated receptors detect biogenic polyamines with distinct motifs via a conserved binding site
Research Article| Volume 297, ISSUE 5, 101268, November 2021; Liang Jia, Shengju Li, Wenxuan Dai, Richard R. Neubig, Qian Li, Weiming Li; doi.org/10.1016/j.jbc.2021.101268

Dual Role of a Rubisco Activase in Metabolic Repair and Carboxysome Organization
Mirkko Flecken, Huping Wang, Leonhard Popilka, Ulrich Hartl, Andreas Bracher, Manajit Hayer-Hartl; bioRxiv 2020.05.16.099382; doi: https://doi.org/10.1101/2020.05.16.099382

Pharmacology

Comparative Anti-inflammatory Effect of Curcumin at Air-Liquid Interface and Submerged Conditions using Lipopolysaccharide Stimulated Human Lung Epithelial A549 Cells
Yue Hu, Yunhua Sheng, Xiaoli Ji, Ping Liu, Liming Tang, Gang Chen, Guiliang, Chenbd; published on ScienceDirect, August 2020, doi.org/10.1016/j.pupt.2020.101939

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling
Wójcik-Pszczoła, K.; Chłoń-Rzepa, G.; Jankowska, A.; Ślusarczyk, M.; Ferdek, P.E.; Kusiak, A.A.; Świerczek, A.; Pociecha, K.; Koczurkiewicz-Adamczyk, P.; Wyska, E.; Pękala, E.; Gosens, R. A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling. Int. J. Mol. Sci. 2020, 21, 4008.

Plant research

Targeted knockout of the gene OsHOL1 removes methyl iodide emissions from rice plants 
Carlessi M, Mariotti L, Giaume F, Fornara F, Perata P, Gonzali S. Sci Rep. 2021;11(1):17010. Published 2021 Aug 23. doi:10.1038/s41598-021-95198-x

Regulation of Vacuole Morphology by PIEZO Channels in Spreading Earth Moss
Ivan Radin, Ryan A. Richardson, Ethan R. Weiner, Carlisle S. Bascom, Magdalena Bezanilla, Elizabeth S. Haswell; bioRxiv 2020.08.27.269282; doi: doi.org/10.1101/2020.08.27.269282

An Improved HRPE-Based Transcriptional Output Reporter to Detect Hypoxia and Anoxia in Plant Tissue
Panicucci, G.; Iacopino, S.; De Meo, E.; Perata, P.; Weits, D.A. Biosensors 2020, 10, 197. https://doi.org/10.3390/bios10120197

Utilization of tomato rootstock as a strategy to increase crop performance under suboptimal soil temperatures
Bristow, Steven Tyler; 2020, Electronic Theses and Dissertations [4361]; http://hdl.handle.net/11714/7692

Cell Biology

WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity
Steib E, Laporte MH, Gambarotto D, et al. WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity. Elife. 2020;9:e57205. Published 2020 Sep 18. doi:10.7554/eLife.57205

Toxicology

Inhibiting endocytosis in CGRP+ nociceptors attenuates inflammatory pain-like behavior
Powell R, Young VA, Pryce KD, et al. Nat Commun. 2021;12(1):5812. Published 2021 Oct 4. doi:10.1038/s41467-021-26100-6

Use of Zebrafish Embryo Assay to Evaluate Toxicity and Safety of Bioreactor-Grown Exopolysaccharides and Endopolysaccharides from European Ganoderma applanatum Mycelium for Future Aquaculture Applications
Wan-Mohtar WAAQI, Ilham Z, Jamaludin AA, Rowan N. Int J Mol Sci. 2021 Feb 7;22(4):1675. doi: 10.3390/ijms22041675. PMID: 33562361; PMCID: PMC7914815.

Ecology

Differences in Homomorphic Sex Chromosomes Are Associated with Population Divergence in Sex Determination in Carinascincus ocellatus (Scincidae: Lygosominae)
Hill P, Shams F, Burridge CP, Wapstra E, Ezaz T. Cells. 2021 Feb 1;10(2):291. doi: 10.3390/cells10020291. PMID: 33535518; PMCID: PMC7912723.

Biophysics

Automatic image annotation for fluorescent cell nuclei segmentation
Englbrecht F, Ruider IE, Bausch AR.; PLoS One. 2021;16(4):e0250093. Published 2021 Apr 16. doi:10.1371/journal.pone.0250093

Physics

R&D of Wavelength-Shifting Reflectors and Characterization of the Quantum Efficiency of Tetraphenyl Butadiene and Polyethylene Naphthalate in Liquid Argon
G.R. Araujo, L. Baudis, N. McFadden, P. Krause, S. Schönert, V. H. S. Wu; arXiv:2112.06675 [physics.ins-det]; doi.org/10.48550/arXiv.2112.06675; Journal reference: Eur. Phys. J. C (2022) 82:442