光学显微镜配件

Alzheimer's disease, a genetic and sporadic neurodegenerative condition, leads to cognitive decline in mid to late life, marked by β-amyloid plaques and tau tangles. With limited treatment options, new investigative strategies are crucial. The Cell DIVE multiplexed imaging solution allows examination of Alzheimer's brain tissue, potentially uncovering new research avenues. Here, we showcase the Cell DIVE image viewer, enabling users to access the full Alzheimer's multiplexed dataset directly in their browser.

在汽车零部件的开发和生产过程中，无论是供应商还是汽车制造商，都必须符合规格要求。这些规格对保持汽车和其他车辆在生命周期内的性能标准和安全运行至关重要[1,2,3]。在满足或超越日益严格的质量标准的同时，对更高效和更具成本效益的零部件开发和生产的需求一直在提高。本文解释了如何用数码显微镜轻松快速地研究和记录零件以确定其是否符合规格要求。

This interview highlights the transformative impact of Mica at Imperial College London. Scientists explain how Mica has been a game-changer, expanding research possibilities and facilitating interdisciplinary collaboration. They explain how detailed live cell imaging with Mica provides more meaningful information, keeping scientists at the forefront of research. The team foresees Mica continuing to open new research avenues, including the study of microfluidics and other advanced applications.

In the webinar entitled "A Multimodal Vitreous Crusade, a Cryo Correlative Workflow from Bench to Beam" a team of experts discusses the exciting world of correlative workflows for structural biology that empower researchers to study fine details of biological structures. Watch and explore the latest developments, instruments, and techniques in cryo workflows for correlative light electron microscopy (cryo-CLEM).

癌症是一种复杂的异质性疾病，由于细胞生长失控而引起。 一个或一组细胞的基因和表观遗传的变化破坏了正常功能，导致细胞自发、不受控制地生长和增殖。

模式生物是研究人员用来研究特定生物学过程的物种。 它们具有与人类相似的遗传特征，通常用于遗传学、发育生物学和神经科学等研究领域。 选择模式生物的原因通常是它们在实验室环境中易于保持和繁殖、生成周期短，或能够产生突变体来研究某些性状或疾病。

在显微镜检查中，景深常被看做经验参数。在实际操作中，会根据数值孔径、分辨率和放大率之间的相关性确定该参数。为了获得最佳视觉效果，现代显微镜的调节设备在景深和分辨率之间实现了最佳平衡，这两个参数在理论上呈负相关。

Pancreatic cancer, with a mortality rate near 40%, is challenging to treat due to its proximity to major organs. This story explores the complex biology of pancreatic ductal adenocarcinoma (PDAC), examining molecular and spatial determinants of tumor aggression in metabolism, apoptosis, and immunity. Access the full Cell DIVE dataset in your browser to delve deeper into these findings.

Colorectal cancer poses a significant health burden. While surgery is effective initially, some patients develop recurrent secondary disease with poor prognosis, necessitating advanced therapies like immunotherapies. Spatial biology approaches, such as multiplexed imaging with Cell DIVE, can provide crucial insights for developing novel treatments. Access the full Cell DIVE dataset in your browser to explore these findings further through the Minerva image viewer.

This article provides an introduction to the recommendations of 21 CFR Part 11 from the FDA, specifically focusing on the audit trail and user management in the context of cell-culture laboratories. It is intended for professionals in the biotechnology and pharmaceutical industries who are responsible for ensuring agreement with 21 CFR part 11 for electronic records and electronic signatures. A digital microscope approach, e.g. with Mateo FL, offers the advantage of more consistent and efficient electronic documentation of cell-culture results compared to a paper-based method.

此外，在对材料样本进行成像时，暗场显微镜还能增强图像对比度。暗场光学对比法利用生物标本结构或材料样本的不均匀特征产生的光散射或衍射。

使用相差光学显微镜，无需染色就可以更大对比度观察各种类型生物标本的结构。

Find out more about Leica super-resolution microscopy solutions and how they can empower you to visualize in fine detail subcellular structures and dynamics.

DIC显微镜是一种宽视场显微镜，在光源镜与聚光镜之间，以及在物镜和相机传感器或目镜之间，都设有偏振滤光器和沃拉斯顿棱镜。

Zebrafish is a valuable model organism with many beneficial traits. However, imaging a full organism poses challenges as it is not stationary. Here, this case study shows how zebrafish larvae can be imaged during stationary periods and easily relocated after movement. The seamlessly integrated widefield and confocal capability of Mica is leveraged to capture fast events, like the heartbeat, with virtually no out-of-focus background noise which is inherent to standard widefield systems.